黑料导航

Federally funded research from the laboratory of Maria Alicia Carrillo Sepulveda, Ph.D., BSN, has produced new findings that advance understanding of the relationship between menopause and cardiovascular disease risk.

Supported by a Research Enhancement Award (R15 grant) from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH),[1] Sepulveda, a vascular physiologist, and a team of student researchers have published new findings in the . Their study explores why cardiovascular disease risk increases after menopause, and yields new insights into how proteins linked to obesity and cardiometabolic disease may also drive cardiovascular risk after menopause.

The publication underscores the strength of student mentorship at the College of Osteopathic Medicine (NYITCOM). Three medical students鈥�Nefia Chacko, Mohit Shah, and Christian Jude-Aspiras鈥攕erved as co-authors, along with 黑料导航 alumna Reia Thomas (B.S. 鈥�25), who is entering NYITCOM鈥檚 Biomedical Sciences, M.S. program, and Associate Professor of Anatomy Aki Watanabe, Ph.D. Notably, Chacko, a 2024 recipient of the American Heart Association Student Scholarship in Cardiovascular Disease, serves as the paper鈥檚 first author.

Experts estimate that only of women receive effective treatment for menopause. If left unaddressed, weight gain caused by menopause often leads to obesity, a major risk factor for cardiovascular disease. Using a female rodent model, the researchers examined blood levels of a hormone called asprosin, which helps to regulate how the body uses energy. Elevated asprosin levels have been linked to conditions like obesity, diabetes, and heart disease. In comparing animals with and without menopause-like changes, the researchers found that post-menopausal animals had higher levels of asprosin and arterial stiffness. These findings may help explain the increased risk of heart disease during this stage of life. The team expects their findings will lead to further investigations into asprosin as a potential biomarker for heart disease after menopause.

鈥淭his publication reflects the scientific productivity of NIH-supported research at NYITCOM and advances our understanding of asprosin as a potential cardiometabolic mediator in women. It also demonstrates the value of embedding medical students in rigorous, federally funded research, a core mission of the mechanism and a training investment with long-term impact on physician-scientists,鈥� says Sepulveda.

Since joining NYITCOM in 2014, Sepulveda has provided many medical and undergraduate students with opportunities to enhance their academic experiences through scientific training in cutting-edge preclinical research. Sepulveda has mentored more than 35 medical and undergraduate students, providing hands-on training in federally funded cardiovascular research. Of those, 22 have gone on to co-author peer-reviewed publications, and five have earned American Heart Association scholarships, among the most competitive awards available to student researchers in cardiovascular science. Chacko is among several participants in NYITCOM鈥檚 Academic Medicine Scholars program from Sepulveda鈥檚 laboratory to receive AHA scholarships in recent years. Other recipients include Jac Lun Lin, Nicole Maddie (D.O. 鈥�24), Risa Kiernan (D.O. 鈥�23), and Benjamin Kramer (D.O. 鈥�19).

[1] This work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number 1R15HL165328-01A1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.